@PeterJones said:
Hopefully, it’s just that it used to point to local config but is now AppData, or similar.
As a scoop user myself, I can confirm that it will configure Notepad++ for portable usage by default.¹ Removing the magic doLocalConf.xml file at %USERPROFILE%\scoop\apps\notepadplusplus\current is probably all that’s needed.
¹ This is one setting that’s not preserved during an upgrade (the other being the autoCompletion folder), while the contents of ${NPP_INSTALLATION_ROOT}\{backup,cloud,plugins,themes,userDefineLangs} are kept in sync by means of junctions between the canonical current folder and the versioned one. Someone should open an issue in the scoop repository, I just haven’t found the free time yet.